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Renálida is an organizational model that transforms healthcare coverage into genuine access. In contexts where older adults are excluded from effective care, Renálida offers early and sustained attention through connection, science and meaning. This is an invitation to trust: change is possible when clinical practice is humanized and purposefully organized.
Anaemia is a frequent complication of chronic kidney disease (CKD) that is associated with reduced quality of life and adverse clinical outcomes. A new analysis suggests that the global burden of anaemia in CKD will rise substantially in the next 25 years.
Since the discovery of PLA2R, several target antigens associated with membranous nephropathy have been identified. This Review describes the distinct clinical associations, pathology and prognostic findings associated with each of the identified target antigens and implications for the reclassification of membranous nephropathy.
This Review examines the bidirectional relationship between hypertensive disorders of pregnancy and kidney disease, which is currently underrecognized, with potential long-term implications for kidney health in both mothers and their offspring. The authors also discuss prevention and management of hypertensive disorders of pregnancy, including kidney health follow-up, and current research gaps.
Although immune checkpoint inhibitors can prolong survival in people with clear-cell renal-cell carcinoma, disease progression is frequent. Here, the authors explore potential mechanisms that might drive intrinsic or acquired resistance to immune checkpoint inhibitors in clear-cell renal-cell carcinoma, including malignant cell-intrinsic and immune-cell factors.
Available evidence supports the existence of functional connections between resident microorganisms and the kidney that are altered in the context of specific kidney diseases. This Roadmap article describes current understanding of the mechanisms by which microorganisms regulate host organ function, highlighting key knowledge gaps that remain to be addressed and opportunities for future research.
