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Concentric demyelination by self-organization: a new hypothesis for Baló's sclerosis

Nature Clinical Practice Neurology volume 3, page E1 (2007)Cite this article

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Arising from: Mowry EM et al. Technology insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis? Nat Clin Pract Neurol 3: 341–348 doi:10.1038/ncpneuro0519

The pathogenesis of concentric sclerosis is a medical enigma. In a recent review1 summarizing the different hypotheses for periodic demyelination, our mathematical model2 is described in a way that requires further clarification.

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References

  1. Mowry EM et al. (2007) Technology insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis? Nat Clin Pract Neurol 3: 341–348

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  2. Khonsari RH and Calvez V (2007) The origins of concentric demyelination: self-organization in the human brain. PLoS ONE 2: e150

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  3. Stadelmann C et al. (2005) Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis. Brain 128: 979–987

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Authors and Affiliations

  1. Département de Mathématiques et Applications, École normale supérieure, Paris, France

    Roman H Khonsari & Vincent Calvez

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  1. Roman H Khonsari
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  2. Vincent Calvez
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Correspondence to Vincent Calvez.

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Khonsari, R., Calvez, V. Concentric demyelination by self-organization: a new hypothesis for Baló's sclerosis. Nat Rev Neurol 3, E1 (2007). https://doi.org/10.1038/ncpneuro0619

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