Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy

Nature Genetics volume 42, page 3 (2010)Cite this article

Subjects

To the Editor:

We note the retraction of a paper published in Nature Genetics in 2003, which had reported that mutations in CLCN2 (NCBI Reference Sequence NC_000003.11), the gene encoding the chloride channel ClC-2, were associated with several subtypes of idiopathic generalized epilepsy1. Despite the retraction, Kleefuß-Lie et al.2 recently asserted that “other major aspects of the work remain unaltered” and that their electrophysiological studies are supported by further work published subsequently2. We believe that their logical argument is flawed and that, in addition, the assertion misrepresents the work of others, including our own.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Haug, K. et al. Nat. Genet. 33, 527–532 (2003); retraction 41, 1043 (2009).

    Article  CAS  Google Scholar 

  2. Kleefuß-Lie, A. et al. Nat. Genet. 41, 954–955 (2009).

    Article  Google Scholar 

  3. Niemeyer, M.I. et al. Physiol. Genomics 19, 74–83 (2004).

    Article  CAS  Google Scholar 

  4. Blanz, J. et al. J. Neurosci. 27, 6581–6589 (2007).

    Article  CAS  Google Scholar 

  5. D'Agostino, D. et al. Neurology 63, 1500–1502 (2004).

    Article  CAS  Google Scholar 

  6. Bösl, M.R. et al. EMBO J. 20, 1289–1299 (2001).

    Article  Google Scholar 

  7. Jentsch, T.J. Crit. Rev. Biochem. Mol. Biol. 43, 3–36 (2008).

    Article  CAS  Google Scholar 

  8. Planells-Cases, R. & Jentsch, T.J. Biochim. Biophys. Acta 1792, 173–189 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro de Estudios Científicos (CECS), Valdivia, Chile

    María I Niemeyer, L Pablo Cid & Francisco V Sepúlveda

  2. Centro de Ingeniería de la Innovación Asociado al CECS (CIN), Valdivia, Chile

    Francisco V Sepúlveda

  3. Institut für Biochemie, Universität Kiel, Kiel, Germany

    Judith Blanz

  4. Département de Pharmacologie, Université de Lausanne, Lausanne, Switzerland

    Muriel Auberson

  5. Max-Delbrück-Centrum für Molekulare Medizin (MDC) and Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany

    Thomas J Jentsch

Authors
  1. María I Niemeyer
    View author publications

    Search author on:PubMed Google Scholar

  2. L Pablo Cid
    View author publications

    Search author on:PubMed Google Scholar

  3. Francisco V Sepúlveda
    View author publications

    Search author on:PubMed Google Scholar

  4. Judith Blanz
    View author publications

    Search author on:PubMed Google Scholar

  5. Muriel Auberson
    View author publications

    Search author on:PubMed Google Scholar

  6. Thomas J Jentsch
    View author publications

    Search author on:PubMed Google Scholar

Corresponding authors

Correspondence to Francisco V Sepúlveda or Thomas J Jentsch.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Niemeyer, M., Cid, L., Sepúlveda, F. et al. No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy. Nat Genet 42, 3 (2010). https://doi.org/10.1038/ng0110-3

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/ng0110-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing