Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Reply to “Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection”

Nature Genetics volume 39, pages 694–696 (2007)Cite this article

Access through your institution
Buy or subscribe

Chan et al. reply:

Tang et al. and Zhi et al. report that in contrast to our findings1, they were unable to find association between homozygosity or heterozygosity of the CLEC4M (L-SIGN) exon 4 tandem repeat polymorphism and SARS CoV susceptibility in the Chinese population. Their data cannot conclusively negate our findings for the reasons below.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chan, V.S.F. et al. Nat. Genet. 38, 38–46 (2006).

    Article  CAS  Google Scholar 

  2. Leung, G.M. et al. Ann. Intern. Med. 141, 662–673 (2004).

    Article  Google Scholar 

  3. Leung, G.M. et al. Ann. Intern. Med. 141, 333–342 (2004).

    Article  Google Scholar 

  4. Miloserdova, O.V. et al. Russ. J. Genet. 38, 87–89 (2002).

    Article  CAS  Google Scholar 

  5. Galinsky, D. et al. Atherosclerosis 129, 177–183 (1997).

    Article  CAS  Google Scholar 

  6. Barreiro, L.B. & Quintana-Murci, L. J. Infect. Dis. 194, 1184–1185 (2006).

    Article  CAS  Google Scholar 

  7. Barreiro, L.B. et al. Am. J. Hum. Genet. 77, 869–886 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Special Administrative Region, China

    Kelvin Y K Chan & Ui-Soon Khoo

  2. Division of Surgery, Oncology, Reproduction Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK

    Vera S F Chan, Yongxiong Chen & Chen-Lung S Lin

  3. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Special Administrative Region, China

    Shea-Ping Yip

Authors
  1. Kelvin Y K Chan
    View author publications

    Search author on:PubMed Google Scholar

  2. Vera S F Chan
    View author publications

    Search author on:PubMed Google Scholar

  3. Yongxiong Chen
    View author publications

    Search author on:PubMed Google Scholar

  4. Shea-Ping Yip
    View author publications

    Search author on:PubMed Google Scholar

  5. Chen-Lung S Lin
    View author publications

    Search author on:PubMed Google Scholar

  6. Ui-Soon Khoo
    View author publications

    Search author on:PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Sex and age distribution of the SARS and control groups in Chan et al. (PDF 14 kb)

Supplementary Table 2

Comparing CLEC4M seven-repeat allele frequencies and percentage homozygosity of Hong Kong random controls (Chan et al.) and Beijing controls (Tang et al.). (PDF 8 kb)

Supplementary Table 3

CLEC4M homozygote and heterozygote distribution among different populations worldwide in Barreiro et al. (PDF 15 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chan, K., Chan, V., Chen, Y. et al. Reply to “Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection”. Nat Genet 39, 694–696 (2007). https://doi.org/10.1038/ng0607-694

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/ng0607-694

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing