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Fine-mapping of an ancestral recombination breakpoint in DCP1

Nature Genetics volume 23, pages 270–271 (1999)Cite this article

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Genetic analysis is necessary to understand the molecular basis of the association between polymorphisms of DCP1 (encoding the human angiotensin-1 converting enzyme (ACE)), cardiovascular disease and quantitative variation of circulating ACE activity. The recent sequencing of 24 kb of DCP1 in DNA samples from 6 founders of CEPH families that originate from France and Utah (along with 6 samples from African Americans) revealed 37 polymorphisms1 that define 3 common haplotypes (H1, H6 and H7) in individuals of European descent. Haplotypes H1 and H7 include the Alu deletion allele2 in intron 16. This work showed "that there is a major genetic subdivision in the deletion clade (H1 and H7) in one of the populations (European-Americans) that enables a more detailed analysis of common cardiovascular traits associated with this polymorphism" (although data for the proposed analysis were not available).

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Figure 1: Extended haplotypes for clades A, B and C.
Figure 2: ACE variation and halotypes.

References

  1. Rieder, M.J., Taylor, S.L., Clark, A.G. & Nickerson, D.A. Nature Genet. 22, 59–62 (1999).

    Article  CAS  Google Scholar 

  2. Rigat, B. et al. J. Clin. Invest. 86, 1343– 1346 (1990).

    Article  CAS  Google Scholar 

  3. Keavney, B. et al. Hum. Mol. Genet. 11, 1745– 1751 (1998).

    Article  Google Scholar 

  4. Villard, E. et al. Am. J. Hum. Genet. 58, 1268– 1278 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Martin Farrall & Bernard Keavney

  2. Tropical Medicine Research Unit, University of the West Indies, Mona, Jamaica

    Colin McKenzie

  3. Centre National de Genotypage, Evry, France

    Marc Delépine, Fumihiko Matsuda & G. Mark Lathrop

Authors
  1. Martin Farrall
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  2. Bernard Keavney
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  3. Colin McKenzie
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  4. Marc Delépine
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  5. Fumihiko Matsuda
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  6. G. Mark Lathrop
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Corresponding author

Correspondence to G. Mark Lathrop.

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Farrall, M., Keavney, B., McKenzie, C. et al. Fine-mapping of an ancestral recombination breakpoint in DCP1. Nat Genet 23, 270–271 (1999). https://doi.org/10.1038/15449

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