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Human genes that limit AIDS

Nature Genetics volume 36, pages 565–574 (2004)Cite this article

Abstract

Discernable genetic variation among people and populations has an important role in infectious disease epidemics, including that of acquired immune deficiency syndrome (AIDS). Genetic association analysis of several large AIDS cohorts implicate 14 AIDS restriction genes, polymorphic variants in loci that regulate HIV-1 cell entry, acquired and innate immunity, and cytokine defenses to HIV-1. The influence and translational impact of these genes on individual and population sensitivity to AIDS is considerable.

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Figure 1: Illustration of how HIV-1 enters cells, suggesting candidate ARGs for inspection.
Figure 2: Predicted survival pattern based on GPI of four composite ARG genotypes from Table 3.
Figure 3: Ability of imputed GPI-based median survival to predict actual AIDS survival.

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  1. Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA

    Stephen J O'Brien

  2. Laboratory of Genomic Diversity, Basic Research Program, SAIC-Frederick, National Cancer Institute, Frederick, Maryland, USA

    George W Nelson

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O'Brien, S., Nelson, G. Human genes that limit AIDS. Nat Genet 36, 565–574 (2004). https://doi.org/10.1038/ng1369

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