The recent characterization of the alcohol* dehydrogenase Aldh1a2 and the cytochrome P450 Cyp26, two enzymes involved in retinoid metabolism, has helped to explain how bioactive retinoids are made and catabolized. By the elegant definition of an Aldh1a2 null mutation as a dominant suppressor of a Cyp26 null mutation, it is now unequivocally demonstrated that the main function of Cyp26 is to degrade endogenous all-trans retinoic acid rather than to synthesize bioactive hydroxylated retinoids.
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Notes
NOTE: Two errors were introduced while preparing this article for press. In two places, Aldh1a2, an aldehyde dehydrogenase, is referred to incorrectly as an alcohol dehydrogenase. This occurs in the first sentence of the strapline and in the last sentence of the paragraph beginning "Although the picture remains incomplete..." The corrected version of this article is available in the PDF format. An erratum will be published in the June issue of the print version of the journal. We regret the errors.
References
Niederreither, K. et al. Nature Genet. 31 (2002); advance online publication (DOI: 10.1038/ng876).
Horton, C. & Maden, M. Dev. Dyn. 202, 312–323 (1995).
Pijnappel, W.W.M. et al. Nature 366, 340–344 (1993).
Sonneveld, E. et al. Dev. Biol. 213, 390–404 (1999).
Duester, G. Eur. J. Biochem. 267, 4315–4324 (2000).
Niederreither, K. et al. Nature Genet. 21, 444–448 (1999).
White, J.A. et al. J. Biol. Chem. 271, 29922–29927 (1996).
Fujii, H. et al. EMBO J. 16, 4163–4173 (1997).
Sakai, Y. et al. Genes Dev. 15, 213–225 (2001).
Abu-Abed, S. et al. Genes Dev. 15, 226–240 (2001).
Thaller, C. & Eichele, G. Nature 327, 625–628 (1987).
Thaller, C. & Eichele, G. Nature 345, 815–819 (1990).
Imam, A. et al. FASEB J. 15, 28–30 (2001).
Buck, J. et al. Science 254, 1654–1656 (1991).
Ulven, S.M. et al. Dev. Dyn. 222, 341–353 (2001).
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Perlmann, T. Retinoid metabolism: a balancing act. Nat Genet 31, 7–8 (2002). https://doi.org/10.1038/ng877
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DOI: https://doi.org/10.1038/ng877
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