Supplementary Figure 2: POP3 shows characteristic features of PYDs present in HIN-200 proteins. | Nature Immunology

Supplementary Figure 2: POP3 shows characteristic features of PYDs present in HIN-200 proteins.

From: The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

Supplementary Figure 2

(a) Amino acid sequence of POP3. The PYD is shaded grey. The predicted α-helices are marked with blue lines (bottom), while the corresponding α-helices of AIM2, as determined by crystal structure1, are marked with a red line (top). (b) ClustalW alignment of the amino acid sequences corresponding to the PYDs of POP3 and human HIN-200 members. (c) ClustalW alignment of all human PYDs. The characteristic amino acid motifs found in HIN-200 members, which are also present in POP3, are highlighted in yellow. (d) Phylogenetic tree cluster analysis of sequences used in b. The HIN-200 cluster, which includes POP3 is highlighted in yellow.

Back to article page