Supplementary Figure 8: Model.
From: B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
Juxtaposed to marginal reticular cells (MRCs) underneath the subcapsular sinus and at the boundary between T and B cell zones, FRCs nurture B cells by producing BAFF. Ablation of FRCs has detrimental effects on B cell homeostasis: the architectural integrity of primary follicles is lost and B cell viability is profoundly decreased, leading to a significant loss of B lymphocytes.
