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Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

Nature Medicine volume 6, page 114 (2000)Cite this article

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To the editor

Exciting results reporting that blockade of the CD40/CD40 ligand pathway by monoclonal antibody against CD40 ligand led to long-term acceptance of renal allografts in monkeys were recently reported in Nature Medicine1 and elsewhere2. Our own group has previously reported that mixed chimerism and renal allograft tolerance are achieved in monkeys conditioned with a multi-modality peritransplant regimen and without long-term maintenance immunosuppression3,4. In an effort to simplify this therapeutic regimen, we tested a monoclonal antibody against CD40 ligand (American Type Culture Collection catalog number 5C8.33) in this protocol. In the first animals treated, we encountered an unusually high incidence of thromboembolic complications, which we thought worthy of reporting.

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References

  1. Kirk, A.D. et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Med. 5, 686–693 ( 1999).

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Authors and Affiliations

  1. Departments of Surgery and Pathology Harvard Medical School Massachusetts General Hospital, Boston, Massachusetts , USA

    Tatsuo Kawai, David Andrews, Robert B. Colvin, David H. Sachs & A. Benedict Cosimi

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  1. Tatsuo Kawai
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  2. David Andrews
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  3. Robert B. Colvin
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  4. David H. Sachs
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  5. A. Benedict Cosimi
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Kawai, T., Andrews, D., Colvin, R. et al. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 6, 114 (2000). https://doi.org/10.1038/72162

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