Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Recognition of tumor blood vessel normalization as a new antiangiogenic concept

Nature Medicine volume 10, page 329 (2004)Cite this article

To the editor:

We found the first evidence of drug-induced normalization of tumor blood vessels in 19701, and described it more definitively in 1972 (ref. 2). This was a new type of drug action. The drug we used was razoxane (ICRF 159; NSC 129943); by normalizing the characteristically chaotic tumor vasculature, it prevented tumor hemorrhages, blood-borne tumor-cell dissemination and metastasis3.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Salsbury, A.J., Burrage, K. & Hellman, K. Br. Med. J. 4, 344–346 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Le Serve, A.W. & Hellman K. Br. Med. J. 1, 597–601 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hellman, K. Clin. Exp. Met. 20, 95–102 (2003).

    Article  Google Scholar 

  4. Horton, J.J. & Wells, R.S. Brit. J. Dermatol. 109, 669–673 (1983).

    Article  CAS  Google Scholar 

  5. Atherton, D.J. et al. Brit. J. Dermatol. 102, 307–317 (1980).

    Article  CAS  Google Scholar 

  6. Olweny, C.L.M. et al. Cancer Treat. Rep. 60, 111–113 (1976).

    CAS  PubMed  Google Scholar 

  7. Kingston, R.D. & Hellman, K. Brit. J. Clin. Pract. 46, 252–255 (1992).

    CAS  PubMed  Google Scholar 

  8. Gilbert, J.M. et al. Brit. J. Surg. 73, 446–450 (1986).

    Article  CAS  PubMed  Google Scholar 

  9. Braybrook, J.P. et al. Clin. Cancer Res. 6, 4697–4704 (2000).

    Google Scholar 

  10. Hellmann, K. & Rhomberg, W. Cancer Treat. Rev. 18, 225–240 (1991).

    Article  CAS  PubMed  Google Scholar 

  11. Hellmann, K. Sem. Oncol. 25 (suppl. 10), 48–54 (1998).

    CAS  Google Scholar 

  12. Hasinoff, B.B. et al. Curr. Med. Chem. 5, 1–28 (1998).

    CAS  PubMed  Google Scholar 

  13. Bakowski, M.T. Cancer Treat. Rev. 3, 95–107 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. Jain, R.K. Nat. Med. 7, 987–989 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. Izumi, Y. et al. Nature 416, 279–280 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Swain, S.M. et al. J. Clin. Oncol. 15, 1333–1340 (1997).

    Article  CAS  PubMed  Google Scholar 

  17. Rybak, S.M. et al. Cancer Res. 63, 2812–2819 (2003).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Windleshaw House, Withyham, East Sussex, TN7 4DB, UK

    Kurt Hellmann

Authors
  1. Kurt Hellmann
    View author publications

    Search author on:PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hellmann, K. Recognition of tumor blood vessel normalization as a new antiangiogenic concept. Nat Med 10, 329 (2004). https://doi.org/10.1038/nm0404-329a

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nm0404-329a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing