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Reply to: “Antibody affinity maturation and respiratory syncytial virus disease”

Nature Medicine volume 15, pages 725–726 (2009)Cite this article

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Delgado et al. reply:

Shaw et al.1 state that our observations indicate that a protective RSV vaccine must elicit affinity-matured neutralizing antibodies for enhanced respiratory disease (ERD) not to occur2. We agree with this statement. We also agree that, ideally, vaccines should present native respiratory syncytial virus (RSV) structures2, although we think that modifications that do not affect the generation of neutralizing antibodies would be acceptable.

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Author information

Authors and Affiliations

  1. INFANT Foundation, Buenos Aires, Argentina

    Maria Florencia Delgado, Pablo M Irusta & Fernando P Polack

  2. Department of Human Science, Georgetown University, Washington, DC, USA

    Pablo M Irusta

  3. Vanderbilt University, Nashville, Tennessee, USA

    Fernando P Polack

Authors
  1. Maria Florencia Delgado
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  2. Pablo M Irusta
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  3. Fernando P Polack
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Corresponding author

Correspondence to Fernando P Polack.

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Florencia Delgado, M., Irusta, P. & Polack, F. Reply to: “Antibody affinity maturation and respiratory syncytial virus disease”. Nat Med 15, 725–726 (2009). https://doi.org/10.1038/nm0709-725b

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  • DOI: https://doi.org/10.1038/nm0709-725b

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