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Efomycine M: an inhibitor of selectins?

Nature Medicine volume 12, page 873 (2006)Cite this article

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In a recent issue of Nature Medicine, Schön et al. characterized efomycine M (Efo-M) isolated from Streptomyces BS1261 as a specific inhibitor of selectins1. The authors showed that Efo-M at low micromolar concentrations is able to block E- and P-selectin interactions with sialyl Lewisx (sLex)-bearing ligands, for example, carcinoembryonic antigen (CEA). Moreover, Efo-M inhibited selectin-mediated leukocyte rolling in vivo and substantially improved the clinical symptoms of two in vivo inflammatory skin models using transplanted human skin biopsies. Thus, Efo-M was reported to function as a pan-selectin antagonist with promising therapeutic potential.

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Figure 1: No specific Efomycine M binding to E-, L- and P-selectins.

References

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Authors and Affiliations

  1. Corporate Research Business Area Inflammation, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Arne von Bonin, Alexandra Rausch, Khusru Asadullah & Thomas M Zollner

  2. Research Center Europe, Med. Chemistry 5, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Bernd Buchmann

  3. Research Center Europe, Enabling Technologies, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Ben Bader & Martina Schäfer

  4. Research Business Area Dermatology USA, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Kristine Venstrom

  5. Research Center Europe, Computational Design and Compound Characterization, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Stephan Gründemann & Judith Günther

  6. Research Center Europe, Microbiological Chemistry, Schering AG, Müllerstr. 178, Berlin, 13342, Germany

    Ludwig Zorn & Reinhard Nubbemeyer

  7. Berlex Biosciences, 2600 Hilltop Drive, Richmond, 94804, California, USA

    Kristine Venstrom & Thomas M Zollner

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  1. Arne von Bonin
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  2. Bernd Buchmann
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von Bonin, A., Buchmann, B., Bader, B. et al. Efomycine M: an inhibitor of selectins?. Nat Med 12, 873 (2006). https://doi.org/10.1038/nm0806-873a

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