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The Quest Trial, a paradigm of HIV collaborative research

Nature Medicine volume 6, page 1194 (2000)Cite this article

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To the editor

A recent News story in your journal addressed the issue of whether there is a commitment to move forward with the development of preventive vaccines for principal infectious diseases, including human immunodeficiency virus (HIV)-1 infection, tuberculosis and malaria1. For HIV-1, although it is accepted that prophylactic vaccines are an urgent priority to prevent new infections, the plight of those already infected must also be considered. Consequently, there is a strong case for promoting the development of therapeutic vaccines in parallel with drug intervention.

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References

  1. Birmingham, K. Industry outlines its perspective on new Third-World vaccine development. Nature Med . 6, 723–724 (2000).

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  2. Finzi, D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1 even in patients on effective combination therapy. Nature Med. 5, 512–517(1999).

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  3. Rosenberg, E. et al. Vigorous HIV-1 specific CD4+ T cell responses associated with control of viremia. Science 278, 1447–1450 (1998).

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Authors and Affiliations

  1. GlaxoWellcome HIV Clinical Research, London, UK

    Li-Ean Goh & Hugh McDade

  2. Royal Free Hospital, London, UK

    Sabine Kinloch

  3. University of Geneva, Geneva, Switzerland

    Luc Perrin

  4. National Centre in HIV, Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia

    David Cooper

  5. Royal Free & University College Medical School, London, UK

    Andrew Phillips

  6. University Medical Centre, Besancon, France

    Bruno Hoen

  7. Laboratoire d'immunologie Cellulaire et Tissulaire, Hopital Pitie Salpetriere, Paris, France

    Brigitte Autran

  8. Karolinska Institutet, Stockholm, Sweden

    Anders Sonnerborg

  9. Montreal General Hospital, Montreal, Canada

    Chris Tsoukas

Authors
  1. Li-Ean Goh
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  2. Hugh McDade
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  3. Sabine Kinloch
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  4. Luc Perrin
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  5. David Cooper
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  6. Andrew Phillips
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  7. Bruno Hoen
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  8. Brigitte Autran
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  9. Anders Sonnerborg
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  10. Chris Tsoukas
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Goh, LE., McDade, H., Kinloch, S. et al. The Quest Trial, a paradigm of HIV collaborative research. Nat Med 6, 1194 (2000). https://doi.org/10.1038/81251

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