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Synthetic vaccines

Immunity without harm

Nature Materials volume 10, pages 166–168 (2011)Cite this article

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Multilamellar lipid vesicles with crosslinked walls carrying protein antigens in the vesicle core and immunostimulatory drugs in the vesicle walls generate immune responses comparable to the strongest live vector vaccines.

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Figure 1: Crosslinked liposomes target and deliver antigen and immunostimulatory drugs to dendritic cells to trigger the generation of memory T cells.
Figure 2: Interbilayer-crosslinked multilamellar vesicles (ICMVs) encapsulating TLR ligands (not shown) and pathogen-specific antigens were synthesized4 from dried liposomes by Mg2+-induced fusion and by crosslinking lipid head groups from opposite lipid bilayers with bilayer-permeable dithiols.

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Authors and Affiliations

  1. Abhinav P. Acharya and Niren Murthy are at the Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332, USA.,

    Abhinav P. Acharya & Niren Murthy

Authors
  1. Abhinav P. Acharya
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  2. Niren Murthy
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Correspondence to Niren Murthy.

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Acharya, A., Murthy, N. Immunity without harm. Nature Mater 10, 166–168 (2011). https://doi.org/10.1038/nmat2977

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