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Reply to: "Reanalysis of Richter et al. (2010) on reproducibility"

Nature Methods volume 10, page 374 (2013)Cite this article

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Würbel et al. reply:

We showed that even simple forms of systematic heterogenization of study populations may increase the reproducibility of animal experiments1. Jonker et al.2 claim that our conclusions are unsupported by the data and are an artifact of pseudoreplication. We disagree with their assessment, which in our view is based on misconceptions and statistical errors as outlined in detail in our Supplementary Note.

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References

  1. Richter, S.H., Garner, J.P., Auer, C., Kunert, J. & Würbel, H. Nat. Methods 7, 167–168 (2010).

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  2. Jonker, R.M., Günther, A., Engqvist, L. & Schmoll, T. Nat. Methods 10, 373 (2013).

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  3. Wolfinger, R.D. Nat. Methods 10, 373–374 (2013).

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  4. Richter, S.H. et al. PLoS ONE 6, e16461 (2011).

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Author information

Authors and Affiliations

  1. Division of Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    Hanno Würbel

  2. Department of Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    S Helene Richter

  3. Department of Comparative Medicine, Stanford University, Stanford, California, USA

    Joseph P Garner

  4. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA

    Joseph P Garner

Authors
  1. Hanno Würbel
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  2. S Helene Richter
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  3. Joseph P Garner
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Corresponding author

Correspondence to Hanno Würbel.

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The authors declare no competing financial interests.

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Supplementary Note (PDF 167 kb)

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Würbel, H., Richter, S. & Garner, J. Reply to: "Reanalysis of Richter et al. (2010) on reproducibility". Nat Methods 10, 374 (2013). https://doi.org/10.1038/nmeth.2446

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