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Proper reporting of predictor performance

Nature Methods volume 11, page 781 (2014)Cite this article

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To the Editor:

In many fields, including the study of genetic variation, prediction methods are essential for interpreting experimental data, and it is important to present their performance in a systematic way. Recently, Kumar et al.1 published a Correspondence about the use of evolutionary information to predict the consequences of amino acid substitutions. The authors claimed that machine-learning classifiers would benefit from training separately at different amino acid conservation levels in order to better predict harmful protein variants.

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References

  1. Kumar, S. et al. Nat. Methods 9, 855–856 (2012).

    Article  CAS  Google Scholar 

  2. Vihinen, M. BMC Genomics 13 (suppl. 4), S2 (2012).

    Article  Google Scholar 

  3. Vihinen, M. Hum. Mutat. 34, 275–282 (2013).

    Article  Google Scholar 

  4. Nair, P.S. & Vihinen, M. Hum. Mutat. 34, 42–49 (2013).

    Article  Google Scholar 

  5. Thusberg, J., Olatubosun, A. & Vihinen, M. Hum. Mutat. 32, 358–368 (2011).

    Article  Google Scholar 

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  1. Department of Experimental Medical Science, Lund University, Lund, Sweden

    Mauno Vihinen

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  1. Mauno Vihinen
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Correspondence to Mauno Vihinen.

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The author declares no competing financial interests.

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Vihinen, M. Proper reporting of predictor performance. Nat Methods 11, 781 (2014). https://doi.org/10.1038/nmeth.3032

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