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Same computational analysis, different miRNA target predictions

Nature Methods volume 4, page 191 (2007)Cite this article

To the editor:

We used the same concept of intersection of some of the programs to obtain high specificity and a manageable number of target genes for subsequent experimental verification in the course of the research for one of our projects. We were particularly interested in miRNA has-miR-155 and some others, and we used only the new generation programs, namely PicTar, TargetScanS and miRanda. We noticed that the intersection of target gene sets we obtained for miR-155 differed strongly from that listed by Sethupathy et al.1, with only one target in common (Supplementary Table 1 online). Similarly the list of intersections and unions of other miRNAs, for example, miR-146 and miR-16 differed (data not shown).

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References

  1. Sethupathy, P., Megraw, M. & Hatzigeorgiou, A.G. Nat. Methods 3, 881–886 (2006).

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Authors and Affiliations

  1. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA

    Xiequn Xu

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  1. Xiequn Xu
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The author declares no competing financial interests.

Supplementary information

Supplementary Table 1

Discrepancy of the two intersections of miR-155. (PDF 11 kb)

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Xu, X. Same computational analysis, different miRNA target predictions. Nat Methods 4, 191 (2007). https://doi.org/10.1038/nmeth0307-191a

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  • DOI: https://doi.org/10.1038/nmeth0307-191a

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