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Quantifying the biodistribution of nanoparticles

Nature Nanotechnology volume 6, page 755 (2011)Cite this article

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In general, transmission electron microscopy (TEM) and quantitative methods such as inductively coupled plasma-mass spectrometry (ICP-MS) are used to study the biodistribution of nanomaterials. For example, ICP-MS can detect the elements of nanomaterials and evaluate their biodistribution quantitatively. However, ICP-MS cannot distinguish between elements that are inherent to the nanomaterials and those that are cleaved or released from them. But, unlike ICP-MS, TEM can detect the presence of nanomaterials and identify their location within tissues and cells. Even though the TEM images in our study1 provide only qualitative information, TEM is invaluable for identifying the biodistribution of the silica and TiO2 nanoparticles.

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References

  1. K. Yamashita, et al. Nature Nanotech. 6, 321–328 (2011).

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Authors and Affiliations

  1. Department of Toxicology and Safety Science, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Osaka, Japan

    Yasuo Tsutsumi & Yasuo Yoshioka

  2. National Institute of Biomedical Innovation, 7-6-8, Saito-Asagi, Ibaraki, 567-0085, Osaka, Japan

    Yasuo Tsutsumi & Yasuo Yoshioka

  3. The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Osaka, Japan

    Yasuo Tsutsumi & Yasuo Yoshioka

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  1. Yasuo Tsutsumi
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  2. Yasuo Yoshioka
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Correspondence to Yasuo Tsutsumi.

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Tsutsumi, Y., Yoshioka, Y. Quantifying the biodistribution of nanoparticles. Nature Nanotech 6, 755 (2011). https://doi.org/10.1038/nnano.2011.220

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