Table a1 ΔBP from Simulations and from the Analytic AUC Formula
Striatum ΔBP | Hippocampus ΔBP | ||||
|---|---|---|---|---|---|
Initial occupancy | Half-life (min) | Simulated fit | AUC ratio | Simulated fit | AUC ratio |
60% | 600 | 52±3% | 51% | 55±8% | 52% |
900 | 55±3% | 53% | 57±7% | 54% | |
1200 | 56±2% | 55% | 59±6% | 56% | |
75% | 600 | 65±2% | 64% | 68±10% | 65% |
900 | 68±2% | 67% | 72±8% | 68% | |
1200 | 70±2% | 69% | 74±8% | 70% | |
90% | 600 | 73±4% | 77% | 85±11% | 78% |
900 | 80±2% | 81% | 89±7% | 82% | |
1200 | 83±2% | 83% | 91±4% | 84% | |
