Abstract
The serotonergic neurotoxin, 3,4-methylenedioxymethamphetamine (MDMA/Ecstasy), is a highly popular recreational drug. Human recreational MDMA users have neurocognitive and neuropsychiatric impairments, and human neuroimaging data are consistent with animal reports of serotonin neurotoxicity. However, functional neuroimaging studies have not found consistent effects of MDMA on brain neurophysiology in human users. Several lines of evidence suggest that studying MDMA effects in visual system might reveal the general cortical and subcortical neurophysiological consequences of MDMA use. We used 3 T functional magnetic resonance imaging during visual stimulation to compare visual system lateral geniculate nucleus (LGN) and Brodmann Area (BA) 17 and BA 18 activation in 20 long abstinent (479.95±580.65 days) MDMA users and 20 non-MDMA user controls. Lifetime quantity of MDMA use was strongly positively correlated with blood oxygenation level-dependent (BOLD) signal intensity in bilateral LGN (rs=0.59; p=0.007), BA 17 (rs=0.50; p=0.027), and BA 18 (rs=0.48; p=0.031), and with the spatial extent of activation in BA 17 (rs=0.059; p=0.007) and BA 18 (rs=0.55; p=0.013). There were no between-group differences in brain activation in any region, but the heaviest MDMA users showed a significantly greater spatial extent of activation than controls in BA 17 (p=0.031) and BA 18 (p=0.049). These results suggest that human recreational MDMA use may be associated with a long-lasting increase in cortical excitability, possibly through loss of serotonin input to cortical and subcortical regions. When considered in the context of previous results, cortical hyper-excitability may be a biomarker for MDMA-induced serotonin neurotoxicity.
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Acknowledgements
This work was supported by NSF (IGERT DGE-0801634 to ALB), NIDA/NIH (R01 DA01537 and R21 DA020149 to RLC, and T32DA021123 to EJC), NIMH/NIH (K01 MH083052 to JUB), and NCRR/NIH (Vanderbilt CTSA Grant UL1 RR024975).
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ALB, JUB, EJC JGL, CJC, NDW, AC, TW, CR D I, CC, and RMS report no potential conflicts of interest related to this report. MSD performed consultation or received compensation from the American Economic Association, Belmont University College of Health Sciences, and the University of Oklahoma Health Sciences Center. RLC received publication royalties from Lippincott Williams and Wilkins and consultant income from the Southwest Michigan First Life Science Fund, the University of West Alabama, Novo Nordisk, and Shire Pharmaceuticals.
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Bauernfeind, A., Dietrich, M., Blackford, J. et al. Human Ecstasy Use is Associated with Increased Cortical Excitability: An fMRI Study. Neuropsychopharmacol 36, 1127–1141 (2011). https://doi.org/10.1038/npp.2010.244
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