Abstract
The neurobiological mechanisms underlying social learning (ie, in which an animal’s learning is influenced by another) are slowly being unraveled. Previous work with systemic treatments shows that dopamine (DA) D1-type receptors mediate social learning in the social transmission of food preferences (STFP) in mice. This study examines the involvement of one brain region underlying this effect. The ventral tegmental area has dopaminergic projections to many limbic structures, including the hippocampus—a site important for social learning in the STFP in rodents. In this study, adult male and female CD-1 mice received a dorsal hippocampal microinfusion of the D1-like receptor antagonist SCH23390 at 1, 2, 4, or 6 μg/μl 15 min before a 30 min social interaction with a same-sex conspecific, in which mice had the opportunity to learn a socially transmitted food preference. Results show that social learning was blocked in female mice microinfused with 6 μg/μl, and in males infused with 1, 4, or 6 μg/μl of SCH23390. This social learning impairment could not be explained by changes in total food intake, or olfactory discrimination. A detailed analysis of the social interactions also revealed that although SCH23390 did not affect oronasal investigation for either sex, drug treatments affected other social behaviors in a sex-specific manner; there was primarily a reduction in agonistic-related behaviors among males, and social investigatory-related behaviors among females. Thus, this study shows that dorsal hippocampal D1-type receptors mediate social learning and social behaviors in male and female mice.
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Acknowledgements
We thank Michelle Kivlenieks, Opoku Adjei-Afriyie, and Angela Meersseman for their help with data collection. The research described here was funded by a research grant to Elena Choleris from the Natural Sciences and Engineering Council of Canada (NSERC). We thank the Ontario Student Assistance Program for graduate scholarships to Richard Matta who was also supported by an Ontario Graduate Scholarship and Queen Elizabeth II Graduate Scholarships in Science and Technology.
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Matta, R., Tiessen, A. & Choleris, E. The Role of Dorsal Hippocampal Dopamine D1-Type Receptors in Social Learning, Social Interactions, and Food Intake in Male and Female Mice. Neuropsychopharmacol 42, 2344–2353 (2017). https://doi.org/10.1038/npp.2017.43
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DOI: https://doi.org/10.1038/npp.2017.43
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