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Oncogenes

One of these things is not like the others

Nature Reviews Cancer volume 16, page 5 (2016)Cite this article

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The RAS isoforms — KRAS, HRAS and NRAS — are known to have similar biological functions; however there have been hints that KRAS might have a unique role in some tumour types. Wang et al. report that oncogenic KRAS, but not HRAS or NRAS, promotes self-renewal properties and tumour initiation by inhibiting non-canonical WNT/Ca2+ signalling.

Although HRAS-V12 and KRAS-V12 confer nearly identical phenotypes to NIH-3T3 cells, the authors noted that KRAS-V12-transformed cells had increased self-renewal and tumour-initiating potential, as assessed using sphere-forming assays and limited and serial transplantation into mice. In addition, knockdown of KRAS-V12 in human pancreatic cancer cell lines (PANC2.13 and PANC1) also reduced sphere formation and tumour initiation.

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References

  1. Wang, M. T. et al. K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163, 1237–1251 (2015)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. One of these things is not like the others. Nat Rev Cancer 16, 5 (2016). https://doi.org/10.1038/nrc.2015.10

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