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Volume 25 Issue 10, October 2025

Ageing and cancer, inspired by the Focus starting on p749.

Cover design: Lara Crow

Editorial

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Comment

  • While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.

    • Marco Demaria
    Comment
  • Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. In this Comment, LaBarge and Binder explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues.

    • Mark A. LaBarge
    • Alexandra M. Binder
    Comment
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Research Highlights

  • In a recent study, Salomó Coll et al. demonstrate that impaired ER-phagy in Kras-mutant pancreatic acinar cells leads to the accumulation of protein aggregates and disruption of acinar cell homeostasis, thereby cooperating with oncogenic KRAS to promote cellular transformation.

    • Daniela Senft
    Research Highlight
  • Chia, Johnson et al. outline a mechanism for how pulmonary viral infections can awaken dormant disseminated cancer cells to enhance metastatic burden.

    • Gabrielle Brewer
    Research Highlight
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Reviews

  • In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.

    • Curtis J. Henry
    • James DeGregori
    Review Article
  • Ageing influences cancer risk through cellular and environmental changes, including the induction of cellular senescence. In this Review, Ye, Melam and Stewart highlight the role of senescent stromal cells in cancer and the therapeutic implications of this.

    • Jiayu Ye
    • Anupama Melam
    • Sheila A. Stewart
    Review Article
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Perspectives

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