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Tumour-Initiating cells

The cell that rocks the tumour

Nature Reviews Cancer volume 17, page 3 (2017)Cite this article

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Latil et al. have shown that the cell of origin of squamous cell carcinomas (SCCs) controls epithelial-to-mesenchymal transition (EMT) and aggressiveness of these tumours. SCCs derived from hair follicles are much more prone to undergo EMT and have more metastatic potential compared with SCCs derived from interfollicular epidermis. Chromatin and transcriptional profiling of these two different epidermal populations during tumorigenesis identified the gene network and different epigenetic states that control tumour initiation and EMT.

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References

  1. Latil, M. et al. Cell-type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition. Cell Stem Cell http://dx.doi.org/10.1016/j.stem.2016.10.018 (2016)

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  1. M. Teresa Villanueva
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Villanueva, M. The cell that rocks the tumour. Nat Rev Cancer 17, 3 (2017). https://doi.org/10.1038/nrc.2016.149

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