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Tumorigenesis

Cancer as a symptom of evolution?

Nature Reviews Cancer volume 17, page 373 (2017)Cite this article

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'other' sources of DNA mutation that lead to tumour initiation

In 2015, Tomasetti and Vogelstein sparked debate about the influence of exogenous, inherited and 'other' sources of DNA mutation that lead to tumour initiation. Now, another paper in Science by Tomasetti, Li and Vogelstein develops their model further and explores how different sources of DNA mutation influence different cancer types.

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References

  1. Tomasetti, C. et al. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 355, 1330–1334 (2017)

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  1. Gemma K. Alderton
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Tomasetti, C. & Vogelstein, B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015)

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Alderton, G. Cancer as a symptom of evolution?. Nat Rev Cancer 17, 373 (2017). https://doi.org/10.1038/nrc.2017.33

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