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Impact of race/ethnicity on molecular pathways in human cancer

Nature Reviews Cancer volume 4, pages 79–84 (2004)Cite this article

Abstract

Understanding the molecular circuitry of the cancer cell is within the grasp of the basic scientist; however, harnessing this knowledge to predict cancer risk requires integration of molecular and population sciences. But, what role, if any, does race/ethnicity have in cancer research and, more specifically, in the nature of genetic and epigenetic alterations that programme the malignant behaviour of the cancer cell?

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Figure 1: Classification of major racial/ethnic groups, based on the migration of modern Homo sapiens.

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Acknowledgements

J.K.W. is supported by the National Institutes of Environmental Health Sciences.

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Authors and Affiliations

  1. the Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue, San Francisco, 94143, California, USA

    John K. Wiencke

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  1. John K. Wiencke
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DATABASES

Cancer.gov

acute lymphoblastic leukaemia

brain cancer

breast cancer

colorectal cancer

gastric cancer

liver cancer

lung cancer

ovarian cancer

pancreatic cancer

prostate cancer

LocusLink

APC

BRCA1

BRCA2

CDKN2A

FY

GATA1

KRAS

Rb

TP53

β-catenin

FURTHER INFORMATION

International Agency for Research on Cancer TP53 mutation database

The Surveillance Epidemiology and End Results (SEER)

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Wiencke, J. Impact of race/ethnicity on molecular pathways in human cancer. Nat Rev Cancer 4, 79–84 (2004). https://doi.org/10.1038/nrc1257

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