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Minimizing the movement

Nature Reviews Cancer volume 7, pages 8–9 (2007)Cite this article

Cancer cells migrate from primary tumours to invade secondary tissues during metastasis. However, it is not known how this process is mediated, although many chemokines and inflammatory mediators have been implicated. Yoshiro Maru and colleagues report in Nature Cell Biology that the S100A8 and S100A9 genes, which encode inflammatory chemoattractants, are involved in the metastasis of tumour cells to the lung.

The authors propose, and previous data support the hypothesis, that lung tissue becomes vulnerable to cancer-cell invasion when tumours are pre-metastatic. So, tumour cells must influence the pre-metastatic niche. The authors used gene-expression profiling to search for genes that might facilitate this process. They focused on the S100A8 and S100A9 genes, because these are strongly upregulated in a mouse model of pre-metastatic tumours. Moreover these inflammatory mediators were not expressed by the lung and melanoma tumour cells that were used in this study.

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ORIGINAL RESEARCH PAPER

  1. Hiratsuka, S. et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nature Cell Biol. 26 November 2006 (doi: 10.1038/ncb1507)

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Authors
  1. Rachel Gonzaga
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Gonzaga, R. Minimizing the movement. Nat Rev Cancer 7, 8–9 (2007). https://doi.org/10.1038/nrc2063

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  • DOI: https://doi.org/10.1038/nrc2063

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