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The evolutionary dynamics of cancer prevention

Nature Reviews Cancer volume 10, pages 526–527 (2010)Cite this article

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Abstract

Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.

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Figure 1: An evolutionary model of a colon crypt highlighting the two distinctive adaptive landscapes.

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Acknowledgements

This work was funded by the Moffitt Cancer Center Physical Sciences-Oncology Center NIH/NCI 1U54CA143970-01.

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Authors and Affiliations

  1. Robert A. Gatenby and Robert J. Gillies are at the departments of Radiology and Integrated Mathematical Oncology at the Moffitt Cancer Center, USA.,

    Robert A. Gatenby & Robert J. Gillies

  2. Joel S. Brown is at the department of Biological Sciences, University of Illinois at Chicago, USA.,

    Joel S. Brown

Authors
  1. Robert A. Gatenby
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  2. Robert J. Gillies
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  3. Joel S. Brown
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Correspondence to Robert A. Gatenby.

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The authors declare no competing financial interests.

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Gatenby, R., Gillies, R. & Brown, J. The evolutionary dynamics of cancer prevention. Nat Rev Cancer 10, 526–527 (2010). https://doi.org/10.1038/nrc2892

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