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Senescence

NF-κB shows its beneficial side

Nature Reviews Cancer volume 11, pages 832–833 (2011)Cite this article

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To identify key molecular players in senescence, Scott Lowe and colleagues carried out a proteomic analysis in human IMR90 fibroblasts following senescence induction by the HRASG12V oncogene. They found the p65 subunit of NF-κB to be particularly enriched in senescent chromatin. In a related study, Clemens Schmitt and colleagues used transcriptomic analysis in mouse lymphoma cells that were engineered to overexpress MYC and the apoptotic inhibitor BCL-2 to investigate senescence that is induced by chemotherapy. In these cells, NF-κB target genes, particularly those encoding secreted cytokines, were upregulated during senescence.

NF-κB inhibition in vivo in lymphomas overexpressing MYC and BCL-2 substantially impaired chemotherapy-induced senescence and reduced the survival of treated mice.

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ORIGINAL RESEARCH PAPERS

  1. Chien, Y. et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 6 Oct 2011 (doi:10.1101/gad.17276711)

  2. Jing, H. et al. Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations. Genes Dev. 6 Oct 2011 (doi:10.1101/gad.17620611)

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Authors
  1. Darren J. Burgess
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Burgess, D. NF-κB shows its beneficial side. Nat Rev Cancer 11, 832–833 (2011). https://doi.org/10.1038/nrc3168

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