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Genomics

Constructing a 'cancerpaedia'

Nature Reviews Cancer volume 12, page 315 (2012)Cite this article

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The two groups of researchers each assembled a panel of hundreds of cancer cell lines and characterized multiple genomic features, gene expression and copy number variation. Each group then conducted a screen with anticancer drugs and used various bioinformatic analyses to correlate drug activity with changes in one or more genes: Barretina et al. profiled 24 drugs in 479 cell lines, and Garnett et al. profiled 130 drugs on 275–507 cell lines. The results showed a number of known interactions between gene mutations and drug sensitivities — such as changes in BRAF that were associated with RAF inhibitors — but several previously unseen connections emerged immediately.

Ewing's sarcoma cells were sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors, suggesting that these drugs could be explored as a treatment.

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ORIGINAL RESEARCH PAPERS

  1. Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603–607 (2012)

    Article  CAS  Google Scholar 

  2. Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483, 570–575 (2012)

    Article  CAS  Google Scholar 

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  1. HudsonAlpha Institute for Biotechnology,

    Chris Gunter

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  1. Chris Gunter
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FURTHER INFORMATION

Cancer Cell Line Encyclopedia

Genomics of Drug Sensitivity in Cancer project

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Gunter, C. Constructing a 'cancerpaedia'. Nat Rev Cancer 12, 315 (2012). https://doi.org/10.1038/nrc3275

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