Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Invasion

An external role for RB?

Nature Reviews Cancer volume 12, page 453 (2012)Cite this article

Subjects

Access through your institution
Buy or subscribe

The effects of loss of the tumour suppressor RB in cancer cells is well characterized, but this paper indicates that RB loss might also affect the stroma. Having found evidence that RB expression is lost in cancer-associated fibroblasts in oropharyngeal tumours, Pickard et al. examined the effect of RB-deficient stromal fibroblasts on the growth of transformed epithelial cells in three-dimensional cultures. These stromal cells increased the invasive growth of the epithelial cells. Further analyses indicated that this was in part through increased expression of keratinocyte growth factor, which promoted the expression of matrix metalloproteinase 1 by the transformed epithelial cells.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Pickard, A. et al. Inactivation of RB in stromal fibroblasts promotes epithelial cell invasion. EMBO J. 29 May 2012 (doi:10.1038/emboj.2012.153)

Download references

Authors
  1. Nicola McCarthy
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McCarthy, N. An external role for RB?. Nat Rev Cancer 12, 453 (2012). https://doi.org/10.1038/nrc3316

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrc3316

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer