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Genomics

Viral vista

Nature Reviews Cancer volume 12, page 582 (2012)Cite this article

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A consortium of scientists used a stringent yeast 2 hybrid (Y2H) screen to examine the interactome of ∼13,000 human open reading frames (ORFs) with ORFs from tumour-causing DNA viruses, including human papilloma virus (HPV) and Epstein–Barr virus (EBV). The authors also expressed the viral ORFs individually in human diploid fibroblasts to examine their effects on the host transcriptome, and to compare protein–protein interactions that were identified in this screen with those found in the Y2H screen. Interactions in the fibroblasts were detected using tandem affinity purification and mass spectrometry (TAP–MS). Comparisons of the Y2H data with the TAP–MS data indicated significant overlap and, overall, 92 transcription factors were either bound or altered by viral ORFs.

proteins encoded by DNA tumour viruses and genetic alterations selected for during tumour development can affect common pathways

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ORIGINAL RESEARCH PAPER

  1. Rozenblatt-Rosen, O. et al. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature 487, 491–495 (2012)Article

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  1. Nicola McCarthy
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McCarthy, N. Viral vista. Nat Rev Cancer 12, 582 (2012). https://doi.org/10.1038/nrc3346

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