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Immunology

TIM3 suppresses antitumour DCs

Nature Reviews Cancer volume 12, page 584 (2012)Cite this article

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Chiba and colleagues confirmed that TIM3 is expressed on tumour-associated DCs isolated from cancer patients. TIM3 was also expressed at high levels on DCs and macrophages — as well as on CD8+ T cells — that were associated with implanted tumours in syngeneic mice. Consistent with innate immune responses being a first line of defence, they found that TIM3 expression was higher, and was induced earlier, on tumour-associated DCs compared with tumour-infiltrating CD8+ T cells. TIM3 induction on immature bone marrow-derived DCs co-cultured with mouse tumour cell lines was synergistically prevented by the blockade of vascular endothelial growth factor receptor 2 (VEGFR2), interleukin-10 (IL-10) and arginase I, which are associated with immunosuppressive signalling.

TIM3 suppresses the activation of tumour-associated DCs to immuno-stimulatory nucleic acids

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ORIGINAL RESEARCH PAPER

  1. Chiba, S. et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nature Immunol. 29 Jul 2012 (doi:10.1038/ni.2376)

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  1. Gemma K. Alderton
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Alderton, G. TIM3 suppresses antitumour DCs. Nat Rev Cancer 12, 584 (2012). https://doi.org/10.1038/nrc3349

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