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Metastasis

Converging targets

Nature Reviews Cancer volume 12, page 793 (2012)Cite this article

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Pencheva et al. compared small RNA profiles of lung metastatic human melanoma cell lines with their poorly metastatic parental cell lines (MeWo and A375 cells) and found that four miRNAs were significantly overexpressed in the derivative cell lines compared with the parental cell lines. Overexpression of three of these miRNAs, miR-199a-5p, miR-1908 and miR-199a-3p, individually in MeWo cells increased lung colonization when the cells were injected into the tail veins of nude mice. Importantly, primary tumour growth was unaffected when the miRNAs were overexpressed, indicating that they have a role in driving metastasis. Furthermore, miRNA profiling of 71 human primary melanoma samples revealed that the expression of miR-199a-5p, miR-1908 and miR-199a-3p was significantly increased in patients who subsequently developed metastasis.

melanoma cell-derived APOE systemically suppresses metastasis

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ORIGINAL RESEARCH PAPER

  1. Pencheva, N. et al. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 8 Nov 2012 (doi:10.1016/j.cell.2012.10.028)

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  1. Gemma K. Alderton
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Alderton, G. Converging targets. Nat Rev Cancer 12, 793 (2012). https://doi.org/10.1038/nrc3411

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