Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

MicroRNAs

Editing changes the meaning

Nature Reviews Cancer volume 12, page 797 (2012)Cite this article

Subjects

Access through your institution
Buy or subscribe

miR-376a* that cannot be edited ... increased in vitro migration and invasion

Shu Wang and colleagues identified reduced editing of miR-376a* (one of five mature miRNAs produced by the cluster) in high-grade human glioma samples, and this correlated with a higher tumour volume on patient magnetic resonance imaging scans. They also showed that miR-376a* editing occurs in glioma cell lines, and used U87 cells to further characterize the biological effects of miR-376a* editing. U87 cells that were selected for metastatic activity by tail-vein injections and reculturing in vitro had higher levels of unedited miR-376a* than parental (less metastatic) U87 cells. Stable expression of miR-376a* that cannot be edited (miR-376a*A) in glioma cell lines increased in vitro migration and invasion, and this was reduced by a stably edited miR-376a* (miR-376a*G; guanosine mimics inosine functionally in miRNAs). Knockdown of miR-376a* in the highly metastatic U87 cells also reduced invasion and migration. Injection of miR-376a*A-expressing U87 cells into the brains of nude mice led to the formation of more invasive tumours and reduced survival time of the animals, compared with tumours formed from miR-376a*G-expressing cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Choudhury, Y. et al. Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J. Clin. Invest. 122, 4059–4076 (2012)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Sarah Seton-Rogers
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seton-Rogers, S. Editing changes the meaning. Nat Rev Cancer 12, 797 (2012). https://doi.org/10.1038/nrc3413

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrc3413

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer