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Metastasis

Epithelial to mesenchymal and back again

Nature Reviews Cancer volume 13, page 3 (2013)Cite this article

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EMT is a developmental process; so, to identify additional regulators of EMT, Ocaña and colleagues screened chick embryos for transcription factors that are involved in early developmental stages. The authors identified the transcription factor paired related homeobox 1 (PRRX1). PRRX1 expression correlated with invasive phenotypes and TWIST1 (an EMT transcription factor) expression in zebrafish embryos and a panel of human cancer cell lines. Furthermore, knockdown of PRRX1 or TWIST1 decreased the ability of BT-549 human breast carcinoma cells to degrade collagen, whereas expression of PRRX1 induced the invasion of HBL-100 breast epithelial cells (which are non-invasive and which express TWIST1 but not PRRX1).

EMT reversion is crucial for metastatic outgrowth

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ORIGINAL RESEARCH PAPERS

  1. Ocaña, O. H. et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 11 Dec 2012 (doi:10.1016/j.ccr.2012.10.012)

  2. Tsai, J. H. et al. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 11 Dec 2012 (doi:10.1016/j.ccr.2012.09.022)

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Authors
  1. Gemma K. Alderton
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Alderton, G. Epithelial to mesenchymal and back again. Nat Rev Cancer 13, 3 (2013). https://doi.org/10.1038/nrc3428

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