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CAFs and miRNAs

Nature Reviews Cancer volume 13, page 8 (2013)Cite this article

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Miltra et al. investigated whether microRNA (miRNA) expression is altered in cancer-associated fibroblasts (CAFs) isolated from patients with ovarian cancer. They found that miR-31 and miR-214 were downregulated and that miR-155 was upregulated. Mimicking these changes in normal fibroblasts resulted in their conversion to a CAF-like phenotype, and blocking these miRNA alterations in CAFs reverted them to a normal phenotype. Gene expression profiling revealed alterations in the expression of chemokine genes, including CCL5, which the authors found to be a target of miR-214.

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ORIGINAL RESEARCH PAPER

  1. Miltra, A. K. et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 21 Nov 2012 (doi: 10.1158/2159-8290.CD-12-0206)

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  1. Nicola McCarthy
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McCarthy, N. CAFs and miRNAs. Nat Rev Cancer 13, 8 (2013). https://doi.org/10.1038/nrc3437

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  • DOI: https://doi.org/10.1038/nrc3437

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