A different kind of chromosome instability

Alderton, Gemma K.

doi:10.1038/nrc3445

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Published: 21 December 2012

Chromosome instability

A different kind of chromosome instability

Gemma K. Alderton

Nature Reviews Cancer volume 13, page 7 (2013)Cite this article

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BUB1 is an activator of the spindle assembly checkpoint, and its altered expression promotes tumorigenesis, which is associated with aneuploidy and chromosome missegregation. Ricke and colleagues generated knock-in mice expressing a kinase-dead BUB1 mutant, which was expressed at normal levels. Surprisingly, these mice did not develop tumours and were not more susceptible to carcinogenesis (unlike mice with altered expression of BUB1), despite aneuploidy and errors in chromosome segregation. This indicates that the type of chromosome instability induced in these knock-in mice does not promote tumorigenesis and so further investigation is required.

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ORIGINAL RESEARCH PAPER

Ricke, R. M. et al. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J. Cell Biol. 3 Dec 2012 (doi:10.1083/jcb.201205115)

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