Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Heterogeneity

A multidimensional overview

Nature Reviews Cancer volume 13, page 439 (2013)Cite this article

Subjects

Although several algorithms already exist to allow an assessment of mass cytometry data, most result in either a loss of individual cell data or the loss of nonlinear relationships. To overcome these limitations, Pe'er and colleagues developed viSNE, which enables the visualization of the data based on an existing algorithm called t-distributed nearest neighbour embedding (t-SNE). Essentially, viSNE allows the best visualization of single-cell data while preserving local and global geometry (non-linear relationships), and these are viewed using viSNE map.

Interestingly, each individual leukaemia sample formed a distinct viSNE map

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Amir, E. D. et al. viSNE enables visualization of high-dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nature Biotech. 19 May 2013 (10.1038/nbt.2594)

Download references

Authors
  1. Nicola McCarthy
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McCarthy, N. A multidimensional overview. Nat Rev Cancer 13, 439 (2013). https://doi.org/10.1038/nrc3549

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrc3549

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer