Finding the GAPs in mTORC1 signalling

Lokody, Isabel

doi:10.1038/nrc3632

Research Highlight
Published: 14 November 2013

Signalling

Finding the GAPs in mTORC1 signalling

Isabel Lokody

Nature Reviews Cancer volume 13, page 825 (2013)Cite this article

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The RAG GTPases directly interact with mTORC1 to form a heterodimer that consists of RAGA or RAGB (RAGA/B) bound to RAGC or RAGD (RAGC/D); the interaction of this heterodimer with mTORC1 is required for mTORC1 activation. In addition, the nucleotide status (that is, whether the RAGs are in a GTP-bound or a GDP-bound form) is also important in mTORC1 activation. Thus, the GAPs, which promote conversion of GTP to GDP, and guanine nucleotide exchange factors (GEFs), which promote conversion of GDP to GTP, are crucial to mTORC1 regulation. Although RAGA/B have been reasonably well studied, the role of RAGC/D in mTORC1 signalling has been less clear.

FLCN–FNIP activity is required for mTORC1 activation.

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References

Tsun, Z.-Y. et al. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2013.09.016 (2013)

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