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Pancreatic Cancer

Spotlight on BRG1

Nature Reviews Cancer volume 14, page 213 (2014)Cite this article

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Matthias Hebrok and colleagues have found that expression of BRG1 (also known as SMARCA4), an ATPase subunit of SWI/SNF complexes, can suppress the formation of intraductal papillary mucinous neoplasm (IPMN; a pre-cancerous lesion of pancreatic adenocarcinoma (PDA)) in mice.

BRG1 is required for PanIN formation in acinar cells

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References

  1. von Figura, G. et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nature Cell Biol. 16, 255–267 (2014)

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  1. Nicola McCarthy
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McCarthy, N. Spotlight on BRG1. Nat Rev Cancer 14, 213 (2014). https://doi.org/10.1038/nrc3709

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