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Leukaemia

Explaining gender bias

Nature Reviews Cancer volume 14, page 766 (2014)Cite this article

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T cell acute lymphoblastic leukaemia (T-ALL) develops more frequently in males than females. Van der Meulen et al. found that the X chromosome gene UTX, which encodes a demethylase of histone H3 lysine 27 trimethylation contains loss-of-function somatic mutations exclusively in males with T-ALL but escapes X chromosome-inactivation in females. They further showed that UTX acts as a tumour suppressor in vitro and in vivo, and that T-ALL with UTX loss is sensitive to a histone methyltransferase inhibitor.

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References

  1. Van der Meulen, J. et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood http://dx.doi.org/10.1182/blood-2014-05-577270 (2014)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. Explaining gender bias. Nat Rev Cancer 14, 766 (2014). https://doi.org/10.1038/nrc3869

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