Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Therapy

Conscious uncoupling

Nature Reviews Cancer volume 15, pages 574–575 (2015)Cite this article

Subjects

Access through your institution
Buy or subscribe

An alternative to kinase inhibition has been proposed that might avoid some of the usual pitfalls of these agents. ERK has been shown to dimerize in response to phosphorylation, and this dimerization is required for signalling in the extranuclear compartment of the cell. The use of molecular biology and genetic methods to prevent this dimerization has previously been shown to prevent tumour development. Therefore, pharmacological inhibition of ERK dimerization presents itself as a possible drug development area.

An alternative to kinase inhibition has been proposed that might avoid some of the usual pitfalls of these agents

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Herrero, A. et al. Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28, 170–182 (2015)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Senior Editor Nature Communications,

    Rebecca Kirk

Authors
  1. Rebecca Kirk
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kirk, R. Conscious uncoupling. Nat Rev Cancer 15, 574–575 (2015). https://doi.org/10.1038/nrc4011

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrc4011

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing