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Metabolism

MYC clocks on

Nature Reviews Cancer volume 15, page 637 (2015)Cite this article

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CLOCK–BMAL1 (also known as ARNTL) and MYC–MAX are transcriptional complexes that bind to E-box sequences in the promoters of the genes that they regulate. Dang and colleagues have suggested previously that deregulated MYC expression might result in the binding of MYC–MAX to genes that are normally regulated by CLOCK–BMAL1. Using U2OS cells that express luciferase under the control of the BMAL1 promoter, the authors showed that MYC activation suppressed the circadian rhythmicity of expression from the BMAL1 promoter, whereas this was maintained in cells expressing a transcriptionally inactive form of MYC. Quantitative PCR indicated that expression of BMAL1 mRNA is suppressed in cells with ectopic MYC expression. Similar results were evident in hepatocellular carcinoma cells established from transgenic mice with conditionally activated MYC transcription.

expression of BMAL1 mRNA is suppressed in cells with ectopic MYC expression

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References

  1. Altman, B. J., Hsieh, A. L. et al. MYC disrupts the circadian clock and metabolism in cancer cells. Cell Metab. http://dx.doi.org/10.1016/j.cmet.2015.09.003 (2015)

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  1. Horizon Discovery Group, Cambridge, UK

    Nicola McCarthy

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  1. Nicola McCarthy
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McCarthy, N. MYC clocks on. Nat Rev Cancer 15, 637 (2015). https://doi.org/10.1038/nrc4036

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