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Cancer susceptibility

Location, location, location...

Nature Reviews Cancer volume 2, page 561 (2002)Cite this article

The authors crossed two mouse strains that carry different alleles for the Scc1 locus — one that conferred resistance to colon cancer, and the other that conferred susceptibility. Different markers surround the allele in these two strains, allowing the identification of offspring in which this region had undergone recombination. By correlating the recombinant map with cancer susceptibility, the precise area that contains Scc1 was located. A single gene, Ptprj , is contained within this region, and an analysis of the homologous region in humans revealed the same. So, Ptprj is the only candidate gene for Scc1.

Ptprj encodes the protein tyrosine phosphatase receptor type J, which has a catalytic domain and eight fibronectin repeats. But what evidence is there that its loss promotes tumorigenesis? Sporadic colorectal adenocarcinomas were screened for loss of heterozygosity in the homologous region in humans, and two linked but independently deleted regions were identified — both of these were deleted in ∼50% of cases. One of them contained PTPRJ in the smallest common deleted region, and, in one tumour only, this gene was deleted. Interestingly, loss of heterozygosity was also observed in some lung and breast carcinomas.

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ORIGINAL RESEARCH PAPER

  1. Ruivenkamp, C. A. L. et al. Ptprj is a candidate for the mouse colon-cancer suseptibility locus Scc1 and is frequently deleted in human cancers. Nature Genet. 31, 295–300 (2002)

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  1. Emma Greenwood
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Greenwood, E. Location, location, location.... Nat Rev Cancer 2, 561 (2002). https://doi.org/10.1038/nrc871

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  • DOI: https://doi.org/10.1038/nrc871

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