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Immunology

Presentation is everything

Nature Reviews Cancer volume 2, page 638 (2002)Cite this article

Tumour-derived exosomes are small vesicles that carry molecules that are involved in antigen presentation, such as MHC class I molecules, heat-shock proteins, tetraspanins and tumour antigens. Zitvogel et al. have previously shown that exosomes derived in cell culture are immunogenic, and the present study indicates that exosomes can also be isolated in large quantities from tumour ascites from patients and that these are also immunogenic. For instance, monocyte-derived DCs loaded with ascitis exosomes from a patient with Mart1-positive melanoma induce differentiation and expansion of tumour-specific cytotoxic T cells that are derived from these patients, even if the tumours themselves are poorly immunogenic. The authors examined ascites from the peritoneal fluid of 10 other patients who had malignant effusions and showed similar reponses in ovarian and breast cancer, in which the exosomes expressed ERBB2 (also known as HER2/neu).

A comparison between primary tumour cell cultures and ascites showed that many more exosomes were harvested from ascitic fluids, and T-cell responses were easier to stimulate with exosomes from tumour ascites.

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References

ORIGINAL RESEARCH PAPERS

  1. Andre, F. et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295–305 (2002)

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FURTHER READING

  1. Ronchese, F. et al. Tumour antigens on tap. Lancet 360, 268 (2002)

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  2. Thiery, C. et al. Exosomes: composition, biogenesis and function. Nature Rev. Immunol. 2, 569–579 (2002)

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Authors
  1. Ezzie Hutchinson
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Hutchinson, E. Presentation is everything. Nat Rev Cancer 2, 638 (2002). https://doi.org/10.1038/nrc893

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  • DOI: https://doi.org/10.1038/nrc893

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