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Acute coronary syndromes in 2011

Walking the tightrope between efficacy and bleeding

Major advances in the diagnosis of acute coronary syndromes (ACS) have occurred in 2011, but physicians treating ACS still walk the tightrope between efficacy and bleeding. Key publications have shed light on this delicate balance and heralded a new era of novel oral anticoagulants for the treatment of ACS.

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Figure 1: Comparison of the results of the APPRAISE-2,5 ATLAS ACS 2-TIMI 56,6 and TRACER7 trials.

References

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Correspondence to Christopher P. Cannon.

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Competing interests

C. P. Cannon has received research grants from Accumentrics, AstraZeneca, GlaxoSmithKline, Intekrin Therapeutics, Merck, and Takeda. He is a member of the advisory board (funds donated to charity) for Alnylam Pharmaceuticals, Bristol-Myers Squibb/Sanofi, and Novartis. He is a clinical advisory with equity in Automedics Medical Systems and has received honorarium for development of independent educational symposia from AstraZeneca and Pfizer. P. Kohli declares no competing interests.

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Kohli, P., Cannon, C. Walking the tightrope between efficacy and bleeding. Nat Rev Cardiol 9, 69–71 (2012). https://doi.org/10.1038/nrcardio.2011.206

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