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Autoimmune cardiac channelopathies: the heart of the matter

Nature Reviews Cardiology volume 14, page 566 (2017)Cite this article

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We thank Jin Li and Ange Maguy for their Correspondence (Autoimmune channelopathies: questions remain. Nat.Rev.Cardiol.http://dx.doi.org/10.1038/nrcardio.2017.110;2017)1 on our Review (Lazzerini, P. E. et al. Autoimmune channelopathies as a novel mechanism in cardiac arrhythmias. Nat.Rev.Cardiol.http://dx.doi.org/10.1038/nrcardio.2017.61;2017)2.

Li and Maguy state that the term “autoimmune cardiac channelopathies” was first introduced by Li et al. in 2013 (Ref. 3). However, we were unable to identify the specific term “autoimmune cardiac channelopathies” in this article3. Conversely, the general term “autoimmune channelopathies” mentioned by Li et al. in their paper3 had been well recognized in the field of neuroscience since 2005 (Ref. 4). In addition, searches on Google Scholar, PubMed, and Scopus indicate that the specific term “autoimmune cardiac channelopathies” had not been used before our Review article in Nature Reviews Cardiology2.

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References

  1. Li, J. & Maguy, A. Autoimmune channelopathies: questions remain. Nat. Rev. Cardiol. http://dx.doi.org/10.1038/nrcardio.2017.110, (2017).

  2. Lazzerini, P. E., Capecchi, P. L., Laghi-Pasini, F. & Boutjdir, M. Autoimmune channelopathies as a novel mechanism in cardiac arrhythmias. Nat. Rev. Cardiol. http://dx.doi.org/10.1038/nrcardio.2017.61, (2017).

  3. Li, J. et al. Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy. Cardiovasc. Res. 98, 496–503 (2013).

    Article  CAS  Google Scholar 

  4. Buckley, C. & Vincent, A. Autoimmune channelopathies. Nat. Clin. Pract. Neurol. 1, 22–33 (2005).

    Article  CAS  Google Scholar 

  5. Korkmaz, S. et al. Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats. J. Am. Coll. Cardiol. 62, 340–349 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Pier Leopoldo Capecchi and Franco Laghi-Pasini are at the Department of Medical Sciences, Pietro Enea Lazzerini, Surgery and Neurosciences, University of Siena, Viale Bracci 16, Siena, 53100, Italy.,

    Pietro Enea Lazzerini, Pier Leopoldo Capecchi & Franco Laghi-Pasini

  2. Mohamed Boutjdir is at the VA New York Harbor Healthcare System, 800 Poly Place, Brooklyn, New York 11209, USA; at the SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA,

    Mohamed Boutjdir

  3. at the SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA,

    Mohamed Boutjdir

Authors
  1. Pietro Enea Lazzerini
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  2. Pier Leopoldo Capecchi
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  3. Franco Laghi-Pasini
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  4. Mohamed Boutjdir
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Correspondence to Pietro Enea Lazzerini.

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Lazzerini, P., Capecchi, P., Laghi-Pasini, F. et al. Autoimmune cardiac channelopathies: the heart of the matter. Nat Rev Cardiol 14, 566 (2017). https://doi.org/10.1038/nrcardio.2017.111

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