A retrospective study of Medicare patients over 65 years of age with stage II colon cancer, showed that adjuvant chemotherapy did not improve overall survival, even in patients with poor prognostic factors. But, does this mean that these patients should not be offered this treatment option?boxed-text
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
Cell Death & Disease Open Access 06 April 2021
-
Serum chitinase activity prognosticates metastasis of colorectal cancer
BMC Cancer Open Access 25 June 2019
-
NCAPH plays important roles in human colon cancer
Cell Death & Disease Open Access 16 March 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gray, R. et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 370, 2020–2029 (2007).
Gunderson, L. L., Jessup J. M., Sargent, D. J., Greene, F. L. & Stewart, A. K. Revised TN categorization for colon cancer based on national survival outcomes data. J. Clin. Oncol. 28, 264–271 (2009).
O'Connor, E. S. et al. Adjuvant chemotherapy for stage II colon cancer with poor prognostic features. J. Clin. Oncol. 29, 3381–3388 (2011).
Sargent, D. J. et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J. Clin. Oncol. 28, 3219–3226 (2010).
André, T. et al. Current issues in adjuvant treatment of stage II colon cancer. Ann. Surg. Oncol. 13, 887–898 (2006).
Niedzwiecki, D. et al. Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581. J. Clin. Oncol. 29, 3146–3152 (2011).
André, T. et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J. Clin. Oncol. 27, 3109–3116 (2009).
Yothers, G. et al. Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 including survival and subset analyses. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2011.36.4539.
Yothers, G. A. et al. The efficacy of oxaliplatin (Ox) when added to 5-fluorouracil/leucovorin (FU/L) in stage II colon cancer [abstract]. J. Clin. Oncol. 29 (Suppl.), a3507 (2011).
O'Connell, M. J. et al. Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin. J. Clin. Oncol. 28, 3937–3944 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare that they have acted as consultants to Sanofi.
Rights and permissions
About this article
Cite this article
Tournigand, C., de Gramont, A. Is adjuvant chemotherapy an option for stage II colon cancer?. Nat Rev Clin Oncol 8, 574–576 (2011). https://doi.org/10.1038/nrclinonc.2011.139
Published:
Issue date:
DOI: https://doi.org/10.1038/nrclinonc.2011.139
This article is cited by
-
ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
Cell Death & Disease (2021)
-
Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia
World Journal of Surgery (2020)
-
Serum chitinase activity prognosticates metastasis of colorectal cancer
BMC Cancer (2019)
-
NCAPH plays important roles in human colon cancer
Cell Death & Disease (2017)
-
The role of adjuvant chemotherapy in stage II colorectal cancer patients
International Journal of Colorectal Disease (2014)